Matthew Berkseth, PhD

Matt Berkseth is currently a researcher in the laboratory of Dr. Lindsey Sloan in the Department of Radiation Oncology at the University of Minnesota. He obtained his PhD from the University of Minnesota in the laboratory of Dr. David Zarkower in the MCDB&G program. He previously earned his BA in Biology from St. Olaf College.

His current research interests include Myeloid-Derived Suppressor Cell (MDSC) biology, radiation therapy, canine and murine models of glioblastoma, and personalized medicine. His previous research interests included sexual development, CRISPR-Cas9 gene editing, embryology, and pediatric brain overgrowth disorders.

PhD Dissertation: “Control of Caenorhabditis elegans sexual development by TRA-1 and its targets

Recent Publications

Radiation Therapy and Myeloid-derived Suppressor Cells: Breaking Down Their Cancerous Partnership. Boorsma K, Berkseth M, Pardoll D, Ganguly S, Kleinberg L, Lawrence J, Odde J, Largaespada D, Terezakis S, Sloan L. Int J Radiat Oncol Biol Phys. 2023 Nov 30:S0360-3016(23)08174-9.  PMID: 38042450 doi: 10.1016/j.ijrobp.2023.11.050

Profiling PI3K-AKT-MTOR variants in focal brain malformations reveals new insights for diagnostic care. Pirozzi F, Berkseth M, Shear R, Gonzalez L, Timms AE, Sulc J, Pao E, Oyama N, Forzano F, Conti V, Guerrini R, Doherty ES, Saitta SC, Lockwood CM, Pritchard CC, Dobyns WB, Novotny E, Wright JNN, Saneto RP, Friedman S, Hauptman J, Ojemann J, Kapur RP, Mirzaa GM. Brain. 2022 Apr 29;145(3):925-938.  PMID: 35355055 doi: 10.1093/brain/awab376

Sexually dimorphic unc-6/Netrin expression controls sex-specific maintenance of synaptic connectivity. Weinberg P, Berkseth M, Zarkower D, Hobert O. Current Biology. 2018 Feb 19;28(4):623-629. PMID: 29429615 doi: 10.1016/j.cub.2018.01.002

TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination. Berkseth M, Ikegami K, Arur S, Lieb JD, Zarkower D. Proceedings of the National Academy of Sciences. 2013 Oct 1;110(40):16033-16038. PMID: 24046365 doi: 10.1073/pnas.1312087110

MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex-determination module. Arur S, Ohmachi M, Berkseth M, Nayak S, Hansen D, Zarkower D, Schedl T. Developmental Cell. 2011 May 17;20(5):677-88.  PMID: 21571224 doi: 10.1016/j.devcel.2011.04.009

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Lab Manager